منابع مشابه
Airway neutrophils and interleukin-17.
It is well known that exacerbations of obstructive airways disease such as asthma and chronic obstructive pulmonary disease are associated with an increased number of neutrophils in the airways. However, the mechanisms behind this phenomenon are poorly understood. There is in vivo experimental evidence that the number of airway neutrophils is controlled by certain T-lymphocytes, but the mediato...
متن کاملNeutrophils, interleukin-17 and obstructive airway disease
There is increasing evidence that an exaggerated accumulation of activated neutrophils is linked to the clinical course of obstructive airway diseases, such as asthma and chronic obstructive pulmonary disease. The present review article focuses on the evidence that the T cell cytokine interleukin (IL)-17 plays a role in orchestrating the accumulation and subsequent activation of neutrophils in ...
متن کاملInterleukin-17 as a recruitment and survival factor for airway macrophages in allergic airway inflammation.
Recent data indicate that the proinflammatory cytokine, interleukin (IL)-17, stimulates certain effector functions of human macrophages. We evaluated whether IL-17 mediates allergen-induced accumulation of airway macrophages and, if so, whether such an effect relates to the control of macrophage recruitment and survival. BALB/c mice were sensitized and challenged with ovalbumin. Three hours bef...
متن کاملInterleukin-17 family and IL-17 receptors.
Interleukin-17 (IL-17) is a pro-inflammatory cytokine secreted by activated T-cells. Recently discovered related molecules are forming a family of cytokines, the IL-17 family. The prototype member of the family has been designated IL-17A. Due to recent advances in the human genome sequencing and proteomics five additional members have been identified and cloned: IL-17B, IL-17C, IL-17D, IL-17E a...
متن کاملDifferential role of the interleukin-17 axis and neutrophils in resolution of inhalational anthrax.
The roles of interleukin-17 (IL-17) and neutrophils in the lung have been described as those of two intricate but independent players. Here we identify neutrophils as the primary IL-17-secreting subset of cells in a model of inhalation anthrax using A/J and C57BL/6 mice. With IL-17 receptor A knockout (IL-17RA-/-) mice, we confirmed that IL-17A/F signaling is instrumental in the self-recruitmen...
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ژورنال
عنوان ژورنال: European Respiratory Journal
سال: 2000
ISSN: 0903-1936,1399-3003
DOI: 10.1034/j.1399-3003.2000.15e28.x